In 1964, the Skatalites and Al Caiola recorded an instrumental version of The Guns of Navarone's main title and released it as "The Guns of Navarone." The melody has been picked up by groups as diverse as the reggae band The Upsetters and the Finnish ska group Jazzbaners.

In 1967 producer Carl Foreman announced plans to film Alistair MacLean's sequel, Force 10 from Navarone, but it was not made until 1978. By that point, Foreman had stepped down as producer, though he was still credited for creating the initial story adaptation. The film focused on a mission sending the survivors from the first film to destroy an enemy bridge in Yugoslavia. Robert Shaw took over Gregory Peck's role, with Edward Fox standing in for David Niven and Harrison Ford for Richard Harris. The film was not as successful as its predecessor.

In My Science Project (1985), a character says "I feel like Gregory Peck in The Guns of Navarone."

The 1987 video game Metal Gear features a mission inspired by The Guns of Navarone.

In 1993, a restored print of The Guns of Navarone premiered as the opening night attraction at the UCLA Festival of Preservation. Under the guidance of UCLA's Bob Gitts, technicians spent two years restoring the film's print and soundtrack to their original condition.

In 1997, BBC Radio 2 presented a two-hour adaptation of MacLean's novel starring Toby Stephens as Mallory and David Rintoul as Andrea.

One of the missions in the 2005 video game Grand Theft Auto: Liberty City Stories is called "The Guns of Leone."

by Frank Miller