Producer Hal Roach capitalized on Constance Bennett's success in Topper by re-teaming her with Billie Burke and director Norman Z. McLeod in another screwball comedy, Merrily We Live (1938). The film co-starred Brian Aherne as a butler who takes charge of a family of wealthy eccentrics. Ironically, Bennett had lost out on the lead in the similar My Man Godfrey (1936) two years earlier.

Topper was among the books and films spoofed in the 1938 Warner Bros. cartoon "Have You Got Any Castles?"

Roach followed Topper with two sequels. The 1939 Topper Takes a Trip reunited Bennett, Roland Young and Billie Burke, but Cary Grant, who had become a star partly as a result of the original's success, declined to participate. He was featured, nonetheless, in a reprise of the car crash from the original. In 1941, Topper Returns starred Young and Burke, with Joan Blondell taking over the role of Marion Kerby.

A television series based on Topper played on CBS from 1953 to 1956. Off-screen husband-and-wife Robert Sterling and Anne Jeffreys played the ghosts, with Leo G. Carroll as Topper.

In 1979, ABC presented a television movie remake starring another married couple, Kate Jackson and Andrew Stevens.

In 1985, Topper became the first film to be fully colorized.

The 1988 comedy hit Beetlejuice, like Topper, featured husband and wife ghosts who help liberate a family from its problems. In the later film, the couple are also killed in an auto accident in the opening of the movie.

by Frank Miller