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The opening and closing cast credits differ slightly in order. Mamie Van Doren, Jerry Lee Lewis, Ray Anthony, Jackie Coogan, Charles Chaplin, Jr. and Diane Jergens are listed as "Guest stars" in the opening credits. Mamie Van Doren and Ray Anthony were married at the time of the film's production. Although a March 7, 1958 Hollywood Reporter production chart adds George Raft to the cast, he did not appear in the released film. High School Confidential! featured a number of second generation Hollywood actors, including John Barrymore, Jr. (billed for the first time as John Drew Barrymore), Charles Chaplin, Jr. and William Wellman, Jr.
This film was the first of three produced by Albert Zugsmith, all of which featured Mamie Van Doren. The other two films, College Confidential and Sex Kittens Go to College were both released in 1960 (see entries above and below). Although similar in theme to High School Confidential, as the titles of the other two films suggest, they were set on college campuses rather than in high schools.