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The hands of pianist Vernon Paris are horribly mutilated in a taxicab accident, and Dr. Gil Harding replaces them with those of a murdered man. Dina (Vernon's sister) and George Britton (his manager) permit the transplant, believing it to be the only hope of Vernon's playing again. Though the operation is a physical success, Vernon is mentally incapable of accepting his new hands. Morose, he visits his girl friend, Elleen Hunter, and is shattered psychologically when she is repelled by his scarred wrists. Consequently, when she knocks over a candlestick and sets fire to her gown, Vernon allows her to burn to death. He visits the home of the cab driver responsible for the accident and hears his son play the piano. Vernon then tries to play, but unable to do so, he attacks the boy, who hits his head on an obstruction and dies. Now bent on total revenge, Vernon kills one of the surgeons who assisted at the transplantation and the young doctor's fiancée. Half-crazed, he goes to an empty concert hall and maniacally pounds a piano keyboard. When his sister and Dr. Harding appear, Vernon grabs the doctor and attempts to strangle him. He is prevented from committing still another murder by the timely arrival of the police.