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Working titles for this film were The Big Shore Leave, Strange Adventure and This Strange Adventure. The picture marked Clark Gable's first film since his return from serving three years in the Army Air Corps. A September 3, 1941 Hollywood Reporter news item indicates that Spencer Tracy was originally set for the part played by Gable. The same news item noted that production was set to begin the following day. According to a February 1946 article in New York Times, actress Greer Garson, commenting on the publicity line associated with the film, "Gable's Back, and Garson's Got Him," reportedly said: "Well, just as long as they didn't say Garson's back, and who wants her!"
Although Hollywood Reporter production charts list actor Larry Burke in the cast, his appearance in the released film has not been confirmed. A May 1945 article in Los Angeles Daily News notes that the film's set of the San Francisco public library was remodelled from the set used for the Waldorf Astoria hotel lobby in the film Weekend at the Waldorf (see below). Lina Romay was formerly a featured singer with Xavier Cugat's band. Adventure marked the feature film debut of actress Barbara Billingsley, who became best known for her role as "June Cleaver" on the popular television series Leave It to Beaver.