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The working title of this film was One Never Knows. Film Daily Year Book erroneously lists the working title as You Can Never Tell. Although Leslie I. Carey and Richard DeWeese are credited onscreen with sound direction, a Hollywood Reporter news item lists Jack Rixie and DeWeese as sound men. You Never Can Tell marked Lou Breslow's directorial debut and actress Sara Taft's feature film debut. "King" was portrayed by "Flame," a German Shepherd who had appeared in the "Rusty" series of films released by Columbia in the 1940s. For additional information on the series, please consult the entry for Adventures of Rusty in AFI Catalog of Feature Films, 1941-50.
According to a April 6, 1951 Variety news item, Bert Granville, an actor who portrayed animals for twenty-five years in vaudeville and on the radio, coached Dick Powell on how to act like a dog. Hollywood Citizen-News reported on June 30, 1951 that Breslow previewed the film before ten married couples, culled from lists given to him by ministers, a rabbi and a priest, apparently to test their reactions to the afterlife subplot. Hollywood Reporter news items add Everett Glass, Ted Strange and Joe Ploski to the cast, but their appearance in the final film has not been confirmed.