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As a boy in the Jewish ghetto of New York, Felix Klauber dreams of becoming a surgeon, while his brother Magnus devises ways to make quick money. After many years of study, Felix earns his medical degree and becomes a physician in the local clinic, where his unorthodox but successful methods earn him the respect of both his patients and his peers. Magnus, however, convinces Felix's mother Hannah that Felix should quit the clinic and open a lucrative private practice on the Upper West Side to better provide for the family, which includes Felix's aging father Meyer and his unmarried sister Birdie. Although troubled by Magnus' plan, Hannah uses her maternal influence and talks Felix into changing his practice. Soon Felix moves to Park Avenue and establishes himself as the doctor "with the million-dollar hands," whose patients' complaints are more imaginary than real. Trapped by his financial success, Felix neglects his family and ignores Jessica, his crippled childhood sweetheart who teaches at the Braille Institute for the Blind. When Felix fails to show up to perform a lifesaving operation on one of her impoverished blind students, Jessica denounces him as a traitor to his heritage and to his profession. Humbled and confused, Felix attends the "Redemption of the First Born" ceremony given in his baby nephew's honor and witnesses the sudden collapse of his father. At his family's urging, Felix agrees to perform surgery on his father, who has an advanced brain tumor, but loses his patient shortly into the operation. Devastated by his father's death, Felix vows never to practice medicine again and falls into a deep depression. However, when Jessica, whose spinal condition has worsened, announces that she is going to take a chance on a dangerous operation that may end her lameness, Felix offers his services and perfectly executes the operation. His confidence restored, Felix returns to medicine and to his ghetto roots.