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Reporter Bill Fenner is sent from New York to cover the case when an American diplomat blows up an international peace conference in Venice, killing all the delegates including himself. Fenner, a former CIA man who was fired when he married suspected enemy agent Sandra Fane, has been brought to Venice by the CIA. They want him to find Sandra, who is hiding from Robert Wahl, the enemy agent who hired her to befriend the American diplomat. Second, Fenner is to obtain a report written by political scientist Pierre Vaugiroud on why the explosion occurred. After he finds Sandra, Fenner contacts Wahl and accepts money in exchange for agreeing to turn over Sandra. Instead, Fenner dresses her as a nun, gives her the money, and puts her aboard a train. Before he joins her, Fenner goes to the office of Mike Ballard, his Venice colleague who has stolen the Vaugiroud report. The office is attacked by a gunman, and although Ballard and his secretary, Giulia Almeranti, are murdered, Fenner escapes with the report. Wahl is waiting when Fenner boards Sandra's train. Sandra confesses to Fenner that she betrayed him to save their lives. When it is discovered that Fenner does not have the report, Wahl kills Sandra and takes Fenner to a secret laboratory and injects him with a drug which will turn him into a robot. The drug fails to take effect; Vaugiroud, also drugged, pleads with Fenner to lead them to where the report is hidden. Although Fenner does so, he suddenly realizes that Vaugiroud's mind has been controlled by the drug, as was the mind of the American diplomat. Fenner kills Wahl and races to the conference in time to prevent Vaugiroud from causing a second explosion.