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The working title of this film was Tarzan's Mate in Peril. During production, the title was changed from Tarzan's Peril to Tarzan's Mate in Peril back to Tarzan's Peril. The film's onscreen title card reads: "Edgar Rice Burroughs' Tarzan's Peril." Tarzan's Peril was the first "Tarzan" picture to be filmed in large part in Africa. According to various Hollywood Reporter news items, exterior filming took place from July to September 1950 in Kenya (British East Africa), including Meru National Park, as well as Uganda and Tanganyika.
After eight weeks of interior shooting at the RKO-Path Studios in Culver City, CA, the production continued filming in Chapultepec Park in Mexico City, according to a news item. Although an October 1950 Hollywood Reporter news item announced that singer Josh White had been signed for a role, his appearance in the final film has not been confirmed. For more information about the "Tarzan" series, consult the Series Index and see the entry for Tarzan, the Ape Man in AFI Catalog of Feature Films, 1931-40, and the entry for Tarzan Triumphs in AFI Catalog of Feature Films, 1941-50.