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According to a February 1950 Hollywood Reporter news item, Warner Bros. originally assigned Charles Tobias and Peter de Rose to write songs for the film, which Louis F. Edelman was to produce. Hollywood Reporter production charts from the first month of production list Francis J. Scheid as sound man; later charts list Leslie G. Hewitt. Warner Bros. production notes add Patricia Hawks, daughter of silent screen star Bessie Love, and the following dancers to the cast: Camille Williams, Shirley Whitney, Joan Haig, Jean Harrison, Crystal White, Beverly Thomas, Diana Mumby and Sally Saunders, but their appearance in the film has not been confirmed. October and November 1951 Hollywood Reporter news items add Donna Ring, Frances Zucco and Chuck Hicks to the cast, but their appearance in the film has not been confirmed. Ramon and Royce Blackburn, the nightclub entertainers known as the Blackburn Twins, performed with Patrice Wymore in the production number "Love Is Still for Free."
According to a September 1951 Hollywood Reporter news item, Michael Curtiz substituted as director for Bruce Humberstone while the latter recovered from the flu. Several reviews noted the differences between the musical film and the James Thurber-Elliott Nugent play upon which it is based, The Male Animal. The freedom of speech issue, precipitated by the professor's announcement that at his next class he would read a letter written by anarchist Bartolomeo Vansetti, is entirely absent from the musical film. The New York Times review noted that the plot of the screenplay shifts attention away from the professor, who almosts loses his wife and job, to the college career of the ex-burlesque dancer, who was a lesser character in the stage play. The Variety review stated that the sociological point made in the stage play was written out of the film.
The 1942 Warner Bros. film The Male Animal, which more closely follows the original play, was directed by Nugent and starred Henry Fonda and Olivia De Havilland. Don DeFore, who played "Shep Slade" in She's Working Her Way Through College, also appeared in the earlier film.