- Victor Mature won the role of Samson over Burt Lancaster, who had a bad back and was considered too young. Henry Wilcoxon was considered, but thought to be too old.
- Director Cecil B. DeMille considered Betty Hutton for the role of Delilah.
- For the scene in which Samson kills the lion, actor Victor Mature refused to wrestle a tame movie lion. Told by director Cecil B. DeMille that the lion had no teeth, Mature replied, "I don't want to be gummed to death, either." The scene shows a stunt man wrestling the tame lion, intercut with closeups of Mature wrestling a lion skin.
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