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According to a Hollywood Reporter news item, Columbia's sales and promotions executives decided to add an exclamation point to the end of the novel's title. The novel on which this film was based was actually set in Georgia at a later period and was about the lynching of an African American, according to the Newsweek review. An October 1955 Daily Variety news item states that Gil Orlowitz was polishing the script, but his contribution to the final film has not been confirmed. Although a Hollywood Reporter news item noted that this was to be cowboy-extra Blackie Whitefield's 2000th film role, his appearance in the released film has not been confirmed.
According to a March 1956 Hollywood Reporter news item, location filming was done at Tucson, AZ. Romson Productions was actor Guy Madison's independent production unit and Wayne Mallory, who played the role of "Tom Shipley", was Madison's brother. According to an August 1956 Hollywood Reporter news item, Reprisal! television commercials were to be run in time slots that immediately followed Madison's popular Wild Bill Hickock television series. Reprisal! marked Romson's first production.