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Frankie Terris runs the numbers racket in his town without serious problems with the law, even though the district attorney would like to find a way to put him in jail. Frankie's sister Louise, who is as devoted to him as he to her, knows that Frankie must be in the rackets and wants him to quit, so he promises to "sell" his business to nightclub owner Manny Robbins and leave with her for a long trip to Europe. Unknown to Frankie, Manny has been coerced into trapping him by the district attorney. When Frankie finds out, he orders his henchmen to kill Manny, but they accidentally kill Manny's son Joe instead. Frankie is convicted of the murder and sentenced to Alcatraz, but before he leaves, a grief-ridden Manny unsuccessfully tries to kill him. When Manny is arrested for attempted murder, some of his men resolve to kill Frankie and follow him on the train heading for Alcatraz. Just before the train leaves, Louise overhears plans for Frankie's murder and goes into one of the train's passenger cars to find a way to warn her brother. At the same time, government agent Bill Adams joins the train and befriends Louise. While the train is traveling through the mid-West, Manny and Frankie have a shootout and Manny is killed. Louise is then consoled by Bill.