- Since star Gary Cooper was right-handed and Lou Gehrig was left-handed, and since Cooper's athletic skills were barely passable right-handed let alone left-handed, the close-up baseball scenes were shot with uniforms in reverse type. Cooper would hit the ball and run to third, and the prints would be reversed.
- While filming the movie, 'Teresa Wright' - who played Lou Gehrig's wife Eleanor Gehrig - wore the actual bracelet that Lou gave to his wife on their fourth anniversary. Gehrig's wife brought the bracelet to the set to be used in the movie. The bracelet is made up of seventeen metal medallions which celebrate the seven World Championships and six All-Star game appearances that Lou Gehrig made. The bracelet is now displayed in the Baseball Hall of Fame.
- Babe Ruth missed several days of shooting during the production because of illness.
- Lefty O'Doul worked with Gary Cooper to improve his batting style.
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