Wild Bill Elliott, Evelyn Young, Dub Taylor, Kenneth Harlan, Ray Teal. Western legend Wild Bill Hickok leads a group of settlers from Kansas to the wilds of Colorado where the Indians are none too friendly.

Virginia Benton and her foreman, Cannonball, are attempting to stop a group of farmers from lynching Dalton Stull, who is taking advantage of a drought in Kansas to foreclose on loans, when their old friend, Wild Bill Hickok, drifts by. Bill agrees to represent them in peaceful negotiations, but when he fails to affect Stull's position, he suggests that the farmers pay off their debt on their equipment and livestock and move to Colorado. Virginia shares her savings and joins the wagon train. Stull and his partner, Wolf Tanner, believe that the group's destination may jeopardize their lucrative fur business, so they ride ahead, taking guns to the Pawnee. During an attack against the settlers by the Pawnee, Stull takes Virginia hostage. At the Pawnee camp, Bill pleads in vain for the farmers' rights, but Cannonball recognizes Tanner and exposes him as the man who had sold guns to the Sioux, which they had used against the Pawnee. Chief Sanche soon realizes that Stull and Tanner are the enemies of his people and decides to allow the farmers to cross peacefully to Colorado. Although Bill says that he is considering a homestead, Virginia knows he will not give up his wanderlust.