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The opening title card to the film reads, "Republic Pictures presents The Three Mesquiteers in Pals of the Saddle featuring," followed by pictures of John Wayne, Ray Corrigan and Max Terhune with their names and character names superimposed. Portions of the picture were filmed in Red Rock Canyon, CA, and at Ray Corrigan Ranch in Simi Valley, CA. A Hollywood Reporter news item on July 14, 1938 noted that Major Keiffer's Cavalry Unit was to be in the film, but their appearance in the released film has not been confirmed. The Neutrality Act noted in newspaper headlines in the film's opening montage was signed into law in 1935. Part of the Act's terms banned the sale of war materials to warring nations. This was the first of the Mesquiteers series in which John Wayne appeared as Stony Brooke, replacing Robert Livingston. For additional information on the series, consult the Series Index and see entry for The Three Mesquiteers.