- Charlton Heston, 'Schieder, Roy' and 'Holden, William' turned down the lead role. Gregory Peck who hadn't worked for a while accepted the lead. William Holden did eventually accept a role in a sequel.
- To make the baboons attack the car in the Windsor Zoo park scene, an official from the zoo was in the backseat of the car with the "leader" baboon, which made all the baboons outside go crazy.
- When the fishbowl falls to the ground, (dead) sardines painted orange were used in place of actual goldfish, which director Richard Donner refused to kill for the sake of making a movie.
- The shot of Lee Remick falling to the floor was done by building the "floor" on a (vertical) wall and dollying an upright Remick backward towards it.
- Having changed its title from The Antichrist to The Birthmark, the film seemed to fall victim to a sinister curse. Scriptwriter 'Seltzer, David' 's plane was struck by lightning; director Richard Donner's hotel was bombed by the IRA; Gregory Peck canceled a flight to Israel, only for the plane he'd chartered to crash, killing all on board; and on day one of the shoot, the principal members of the crew survived a head-on car crash. The jinx appeared to persist well into post-production, when special effects artist John Richardson was injured and his assistant killed in an accident on the set of Bridge Too Far, A (1977).
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