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The working title of this film was No Highway. The picture was reviewed by Variety under the title No Highway, which was also the British release title. As noted in contemporary sources, the picture was filmed on location in Denham, at Denham Studios. An November 11, 1949 Hollywood Reporter news item reported that Newfoundland would also be a location site, but it has not been determined if any of the picture was shot there. A modern source lists Blackbushe Airport, in Hampshire, England, as an additional location. November 1950 Hollywood Reporter news items noted that James Stewart underwent an emergency appendectomy in London while the film was in production.
According to a August 22, 1951 Los Angeles Daily News article, a special advance showing of No Highway in the Sky was to be held that night in Los Angeles as a tribute to Pulitzer-Prize-winning photographer Frank Filan. Filan, who was ill at the time of the screening, was best known for his photographs of the Marine invasion of Tarawa during World War II. A modern source adds the following names to the crew credits: Production Supervisor Robert Dearing; 2nd Unit Director Herbert Mason; and Marlene Dietrich's ward Christian Dior. On April 28, 1952, Stewart and Dietrich reprised their roles for a Lux Radio Theatre broadcast of the story, which co-starred Evelynne Eaton.