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According to a Hollywood Reporter news item, Milton Gunzberg's Natural Vision Corp., a company specializing in 3-D pictures, was set to make the film with Alex Gottlieb, but withdrew from the project due to financing delays. Gottlieb produced the picture in standard format, with financing from Chemical Bank & Trust Co. and three Chicago backers, headed by David Bright. According to a July 1953 Los Angeles Daily News news item, Gottlieb approached Frank Tashlin to write the picture, and Tashlin agreed to do the screenplay in two to three weeks, on condition that he also be allowed to direct it. Tashlin completed the script in two weeks, and shot it in sixteen days. The director attributed his speed to the fact that both Marie Wilson and Robert Cummings had extensive television experience, Wilson on the My Friend Irma program, and Cummings on My Hero. Reviewers also pointed out that Cummings' character in Marry Me Again was similar to the one he played on My Hero, a bumbling real estate agent named "Robert S. Beanblossom."
As noted in the Los Angeles Daily News news item, Tashlin postponed his own wedding to supporting player Mary Costa in order to direct the film. The couple married shortly after production was completed. Costa, who made her screen acting debut in the picture, was an opera singer and later provided the voice of "Sleeping Beauty" in Walt Disney's 1959 film of the same name . Wilson was married to associate producer Robert Fallon at the time of production.