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Although the film's onscreen credits contain a copyright statement, the title does not appear in the copyright registry. The picture opens with a voice-over narrator discussing the possibility of a strange species of man-beast said to live in the Himalayan mountains between India and Tibet. Virginia Maynor was billed in some later films as Asa Maynor, and Lloyd Cameron was also billed in some later films as Lloyd Nelson. Although Rock Madison is given top billing for playing the role "Lon Raynon," there is no character of that name in the film. A modern source states that Rock Madison was a name made up by producer-director Jerry Warren to make his cast seem larger.
Man Beast marked Warren's first production and the first production of Associated Producers, Inc. Brianne Murphy, who was billed as Bri Murphy in the film, and was married to Warren, went on to become the first female director of photography invited to join the American Society of Cinematographers. Murphy, who joined the union in 1973, remained its only female member for fifteen years. Among the many films dealing with the Yeti are the 1954 United Artists production Snow Creature (see below) and the 1957 Twentieth Century-Fox production The Abominable Snowman.