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According to an article in Life, the serum flying sequence in this film was based on an actual incident in which producer David O. Selznick attempted to have serum flown from New York for his critically ill brother Myron, who had pneumonia. A news item in Hollywood Citizen-News reports that Edmund E. Fellegi, a special effects technician, plunged to his death from a forty foot catwalk from which he was releasing balloons for the New Year's Eve party scenes in this picture. Oscar Levant, in his autobiographical writings, states that he gave Selznick some musical material for this film. In February 1940, Carole Lombard and Fred MacMurray appeared in a Lux Radio Theatre version of this story, and in December 1945, James Stewart and Marsha Hunt appeared in another Lux Radio Theatre version.