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According to Life, the picture was filmed aboard the freighter the S.S. Munami at Wilmington Harbor, CA. The film marked the screen debut of stage actress Mildred Natwick. This was the first production of John Ford's Argosy Corp. Modern sources note that under his Fox contract, John Ford was allowed to make one feature per year outside the studio. To make this film, he and Walter Wanger set up Argosy. The next Argosy production was The Fugitive, made in 1947. The Long Voyage Home was nominated for the following Academy Awards: Best Black and White Cinematography, Best Film Editing, Best Original Score, Best Special Photographic Effects, Best Sound and Best Screenplay. It also was included in the National Board of Review's "ten best" list of 1940.