Onscreen credits state that the film was based on a work by Louis Joseph Vance, but no specific work has been identified as the film's source. Lone Wolf and His Lady marked the first time that the character of "Michael Lanyard, The Lone Wolf," was played by Australian actor Ron Randell, and the character of "Jamison" was played by Alan Mowbray. For additional information on the series, please consult the Series Index and see the entry for The Lone Wolf Spy Hunt in the AFI Catalog of Feature Films, 1931-40; F3.2563.