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The working title of this film was Billionaire. The picture opens with a prologue that traces the history of the "Clement" family. According to a November 1959 Hollywood Reporter news item, Tommy Rall tested for a role, but he did not appear. According to studio publicity materials contained in the film's production file at the AMPAS Library, the project was initially conceived as a vehicle for Yul Brynner. When Brynner was not available, Gregory Peck was signed for the lead, but backed out because he thought the part was too slight. After the studio's attempt to hire Charlton Heston failed, Stephen Boyd tested for the role. According to a December 10, 1959 Hollywood Reporter news item, Marilyn Monroe was intent on securing Rock Hudson as her co-star.
Studio publicity noted that playwright Arthur Miller, Monroe's husband at the time, rewrote and expanded her role of "Amanda," although the extent of Miller's actual contribution to the film has not been determined. The Variety review listed the character played by Wilfrid Hyde White as "John Wales," but he is addressed as "George Wales" in the film. The production was halted due to a Screen Actors Guild strike, which ran from 7 March-April 18, 1960. Let's Make Love marked the motion picture debut of British pop star Frankie Vaughan and the American screen debut of French singing star and actor Yves Montand. The picture was nominated for an Academy Award for Scoring of a Musical Picture.