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Pre-production news items in Hollywood Reporter yield the following information about this production: Terry Moore and Joan Collins were both considered for the female leads. Actress Lupita Tovar, the mother of actress Susan Kohner, is included in the cast in an April 1956 Hollywood Reporter news item, but she did not appear in the film. An early May 1956 Hollywood Reporter news item adds that rodeo stars Phil Rawlins and Erwin Neal were assigned to the cast, but their appearance in the completed film has not been confirmed.
The Last Wagon was filmed on location in Sedona, AZ, at the mouth of Oak Creek Canyon. In an article in the New York Times, director Delmer Daves described the difficulty he had in finding a pristine location for the film, as his previous western, Broken Arrow, had popularized the region.