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Hollywood Reporter news items yield the following information about this film: In October 1955, Samuel Goldwyn, Jr. bought the rights to Frederic Wakeman's novel and Luther Davis' play. By September 1956, Jerry Wald had acquired the rights to both the novel and play. In April 1957, a news item announced that Dan Dailey was to star with Cary Grant and Jayne Mansfield. Los Angeles Times news items add that in October 1956, Wald was considering George Montgomery for one of the leads. By December 1956, it was announced that Wald wanted Richard Widmark, who also starred in the Broadway version of Davis' play, to appear.
Although a May 1957 Hollywood Reporter news item states that King Donovan was added to the cast, but he was not in the released film. A May 1957 Hollywood Reporter news item notes that location filming took place in San Francisco. Although onscreen credits read "introducing Suzy Parker," Kiss Them for Me did not mark noted fashion model Parker's screen debut, but rather her first major role. Parker's first film was the 1957 release Funny Face.