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Harold Grove, a London musuem curator, is killed while examining a statue that was the sole treasure to survive a warehouse fire. Grove's mentally unbalanced assistant, Arthur Pimm, who lives alone with the decomposed corpse of his mother, becomes convinced that the statue possesses supernatural powers. Jim Perkins, an American museum representative, uncovers an inscription which suggests that the statue may be the famous 16th century Golem from Prague. Pimm, after learning the history of the Golem, removes an ancient Hebrew scroll from inside the statue and places the scroll under its tongue, thereby becoming its master. Passed over for the position of curator vacated by Grove's death, Pimm orders the Golem to murder Grove's successor and to destroy a bridge. Meanwhile, Perkins incurs Pimm's hatred by romancing his girl friend, Ellen, Grove's daughter. Inspector White of Scotland Yard discovers the body of Pimm's mother and has Pimm committed to a prison mental hospital. But, using mental telepathy, Pimm summons the Golem to help him escape, abducts Ellen, and takes her, along with his mother's coffin, to a country mansion owned by the museum. They are followed by Inspector White, Perkins, and an Army unit equipped with a small atom bomb. Perkins rescues Ellen before the bomb explodes, destroying Pimm and the mansion. The Golem, unharmed, disappears into the sea.