- Patrick McGoohan was filming his famous TV series "Prisoner, The" (1967) at the time he appeared in this movie. In order to allow him to take time off from his TV series, the episode "Do Not Forsake Me Oh My Darling" was written in which McGoohan's character, Number Six, has his mind transferred into the body of another man!
- This film was originally shown in Cinerama venues. In order to put it into these theatres, MGM pulled 2001: A Space Odyssey (1968) while it was still having a successful run.
- In the era before VCRs, 'Howard Hughes' would call the Las Vegas TV station he owned and order them to run a particular movie. Hughes so loved Ice Station Zebra that it aired in Las Vegas over 100 times.
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