- James Brown was originally slated to do the music after his work on Black Caesar (1973) was so well received, but American International Pictures executives changed their minds after rejecting the music Brown delivered for Slaughter's Big Rip-Off (1973). Subsequently, the music was done by Motown artist Edwin Starr and Brown's rejected music was used for the album, "The Payback".
- Due to the success of the first film featuring 'Tommy Gibbs' , Black Caesar (1973), AIP wanted a second film. Unfortunately, Fred Williamson was filming That Man Bolt (1973) during the week from Monday to Friday, and director 'Larry Cohen' was busy making It's Alive! (1974/I), but they made this sequel concurrently by filming the majority of it at weekends.
- Cohen filmed some of the scenes with the same crew and equipment as It's Alive, and due to Williamson's other film commitments he had to make most of the film with a stand-in, Williamson himself only really appearing in the close-ups. The close-ups were filmed in LA, where Williamson was based, and the rest of the film was filmed on location in New York.
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