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The working title of this film was Baptism of Fire. The sequence in which "Lt. Sam Prior" and his men blow up the bridge occurs before the opening credits, which contain the following written statement: "Appreciation is expressed to the Department of Defense, the Department of the Army, and the Corps of Engineers for their cooperation in the production of this film." September 1952 Hollywood Reporter news items announced that Craig Hill had been assigned to the "top featured role" in the film, and that Rev. Leonidas C. Contos would be in the cast, but neither of them appear in the released film. An August 1952 Hollywood Reporter news item includes nightclub singer Jimmy Bays in the cast, but his appearance in the completed picture has not been confirmed.
According to Hollywood Reporter news items, most of the picture was shot on location at Ft. Leonard Wood, MO. Soldiers appeared as extras, and the Army Corps of Engineers built a 460-foot M-2 floating pontoon bridge for use in the film, according to studio publicity. According to a Hollywood Reporter news item, special effects crew member Jess Wolf died from injuries suffered while working on a dynamite blast for the film.
The Hollywood Reporter reviewer commented that the film was notable for attempting its "hitherto untouched subject of other nationalities in the UN struggle against the reds." According to studio publicity, production head Darryl Zanuck ordered the production unit to fill every Greek role of the all-male cast with an actor of Greek parentage. These included Alexander Scourby, Nick Dennis, John Verros and Alberto Morin. The chaplain in the film was played by Rev. Dr. Nicon D. Patrinakos, the priest of the St. Nicholas Greek Orthodox Church of St. Louis. The Glory Brigade marked the producing debut of William Bloom and the directorial debut of Robert D. Webb.