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The working title of this film was The South American Way. Material contained in the Twentieth Century-Fox Produced Scripts Collection at the UCLA Theater Arts Library discloses that after writer Roman Romero drafted a preliminary outline for this film, studio head Darryl Zanuck decided that he wanted to make a "South American" Kentucky (a popular 1938 Fox film). Novelist John O'Hara also worked on a version of the screenplay, but his contribution to the final film has not been determined. According to news items in Hollywood Reporter, an ailing Alice Faye was replaced by Betty Grable, and Cesar Romero, suffering from para-typhoid, was replaced by Leonid Kinskey. Another item in Hollywood Reporter notes that J. Carroll Naish's success in a comedy role in this film prompted Fox to assign him to the 1941 film That Night in Rio. Modern sources include actress Elena Verdugo in the cast in a bit role and note that this May have been her first film. Down Argentine Way was nominated for Academy Awards in the Art Direction (Color) and Cinematography (Color) categories. Harry Warren and Mack Gordon's song "Down Argentine Way" was also nominated for an Oscar.