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The novel was published in England under the title A Cure of Flesh. The working titles of this film were The Last Adam and Life's Worth Living. According to a memo from Will Rogers to a Fox studio executive, he objected to the title Life's Worth Living and preferred instead Ol' Dr. Bull. Motion Picture Daily reported a story that during the production, when two writers suggested to director John Ford that he reshoot a scene from a different angle, he told them, "Better consult Mr. Rogers. He does most of the directing in this picture." According to news items and information in the Twentieth Century-Fox Records of the Legal Department at the UCLA Theater Arts Library, Boots Mallory was originally cast as "Virginia Banning." According to Hollywood Reporter, Andy Devine was loaned from Universal. A pre-production news item stated that Charles Grapewin was to play a featured role.
According to correspondence in the MPAA/PCA Collection in the AMPAS Library, a number of changes were made by Fox in the script for this film after objections by the Hays Office. The most significant of these changes involved dropping all references to abortion in the scene between Dr. Bull and Virginia Banning, and the changing the character of Larry Ward, who suffered from a venereal disease in the original, to a hypochondriac suffering from imaginary ills. This film was re-released by Twentieth Century-Fox on February 5, 1937. Modern sources credit B. F. McEveety as unit manager and Robert Parrish as a cast member.