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The opening titles include the following written statement: "Nothing in this picture is intended to minimize the importance of the drug 'Amphetamine' when properly used under a doctor's prescription. However, as with any drug, when taken to excess, the results can be disastrous." According to a April 1, 1957 Hollywood Reporter news item, actor Tom Lockwood was to make his debut in Death in Small Doses, but his appearance in the released film has not been confirmed.