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The working title of this film was Confidential Report on Collins College. Albert Zugsmith's opening credit reads: "Produced and directed by Albert Zugsmith." According to a January 13, 1960 Hollywood Reporter news item, Tuesday Weld was originally cast in College Confidential, but withdrew to appear in 1960 Twentieth Century-Fox film High Time (see below). In the trial scene, when Mamie Van Doren's character, "Sally Blake," stands to testify, Walter Winchell identifies her as "the Mamie Van Doren type." At the end of the scene, "Steve McKinter" quotes from Act I, Scene 5 of Shakespeare's Hamlet. Although a January 28, 1960 Hollywood Reporter item states that Hearst feature writer Dorothy Kilgallen would play herself, she does not appear in the final film.
Hollywood Reporter news items add Skip Garner, Irwin Berke, Herb Silvers, Bunni Bacon, Gerrie Bender, Harold Lloyd, Jr., Barbara Baxter and Rhoda Williams to the cast, but their appearance in the final film has not been confirmed.
College Confidential followed Zugsmith's 1958 M-G-M production, High School Confidential!, which was directed by Jack Arnold, starred Russ Tamblyn and January Sterling and featured Van Doren.(see below). Zugsmith also directed, produced and wrote another college romp in 1960, Sex Kittens Go To College, which shared some of the same cast as College Confidential, including, Mamie Van Doren, Mickey Shaughnessy, Woo Woo Grabowski, Pamela Mason, Arline Hunter and singer Conway Twitty (see below).