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The working titles of this film were Manhattan Love Song and The World Is Ours. Fox could not use the title Manhattan Love Song because it had already been claimed by Monogram for their 1934 picture (see below). Kathleen Norris' novel first appeared serially in Collier's (15 July-16 September 1933). A Hollywood Reporter news item noted that writer/actor James Gleason was signed to be the dialogue director of the film, but this claim has not been confirmed. Modern sources include Mischa Auer in the cast. Change of Heart marked the screen acting debut of Drue Leyton, and the twelth and final picture of popular love team Janet Gaynor and Charles Farrell. Gaynor and Farrell's first picture together was the enormously successful 1927 Fox film Seventh Heaven, which, along with their next film, Street Angel, and the picture Sunrise, earned Gaynor the first Academy Award for Best Actress. Their first sound picture, 1929's Sunny Side Up ensured their continued strength at the box office. Among their other films in the 1930s were Delicious and Tess of the Storm Country (see below).