Chloe, a diamond-clad, bootie wearing Beverly Hills Chihuahua enjoys her luxurious lifestyle so much, she hardly notices Papi, a tough looking Chihuahua who happens to be head-over-paws for the pampered pooch. But when Chloe gets lost in the rough streets of Mexico with only a street-wise German Shepherd to help her find her way home, Papi heads south of the border--joining forces with a motley crew: two humans, a sly rat and a nervous iguana--to rescue his true love.

Chloe, a diamond-clad, bootie wearing Beverly Hills Chihuahua enjoys her luxurious lifestyle so much, she hardly notices Papi, a tough looking Chihuahua who happens to be head-over-paws for the pampered pooch. But when Chloe gets lost in the rough streets of Mexico with only a street-wise German Shepherd to help her find her way home, Papi heads south of the border--joining forces with a motley crew: two humans, a sly rat and a nervous iguana--to rescue his true love.