Larry is a big city health inspector who is happy with his usual beat of greasy spoon diners and low-rent ethnic restaurants. But his easygoing life is turned upside-down when he's saddled with a straight-arrow rookie partner and assigned the biggest case of his career: investigating an outbreak of mysterious food poisonings at the city's swankiest restaurants. Infuriating restaurateurs with his bad manners, Larry still manages to charm a sweet, shy waitress into a budding romance. But when his unorthodox methods cost him his job, Larry has to go undercover to bring the conspirators to justice and "Git-R-Done!"

Larry the Cable Guy is a health inspector assigned to investigate a series of food poisoning incidents at the city's top restaurants.