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Newsreel footage documents the proceedings of the Senate Committee to Investigate Crime and Interstate Commerce during its hearings in New York City and Washington, D.C., held between 12 March 1951 and 27 March 1951. The committee, chaired by Senator Estes Kefauver (D-TN), consists of Senator Charles H. Tobey (R-NH), Senator Herbert R. O'Conor (D-MD), Senator Lester C. Hunt (D-WY), Senator Alexander Wiley (R-WI) and committee Chief Counsel Rudolph Halley. The committee's mission is to expose alleged members of organized crime, their illegal activities and their possible connections to government officials. The main witnesses called to testify are mobster Frank Costello, reputedly the head of the largest criminal syndicate in New York; Virginia Hill, the longtime girl friend of the late gangster Bugsy Siegel; and former New York mayor William O'Dwyer. The nervous Costello, accompanied by his attorney, George Wolf, often refuses to answer questions directly and once, pleading illness, walks out on the proceedings. In one exchange with Sen. Tobey, Costello asserts that he is a good American because he pays his taxes. Hill, well-known for her abrasive manner and association with gangsters, verbally spars with the committee members and often provokes laughter from the courtroom audiences with her acerbic comments. O'Dwyer, currently serving as the U.S. Ambassador to Mexico, answers questions about misusing his mayoral power to impede investigations into racketeering. O'Dwyer attempts to deflect attention from himself by accusing Sen. Tobey of being involved with New York bookmakers but is unsuccessful and ultimately apologizes. Other witnesses whose testimony is heard include gambler Frank Erickson; stevedore and strikebreaker Anthony Anastasia; former Water Supply Commissioner James J. Moran; New York fire official John P. Crane; Joe Adonis; and Jacob "Greasy Thumb" Guzik.