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There is a slight difference in the cast order between the opening credits and the closing cast list. A New York Times article of October 15, 1950 reported that The Big Break was about to begin production at Camp Fieldstone in Monroe, NY and in New York City. The report indicated that the film would be photographed by Boris Kaufman over a period of a month, on a budget of "under $100,000," and that distribution arrangements would be made after completion of production. Documents in the film's file in the MPAA/PCA Collection file at the AMPAS Library confirm the film's start date and give January 22, 1951 as the date of issue of the PCA seal. The extent of Kaufman's contribution to the completed picture, if any, has not been confirmed. Hollywood Reporter news item of September 2, 1952 stated that Madison Pictures of New York had acquired worldwide distribution rights to the film.
The Big Break marked the feature film debut of actor James Lipton. From 1952 to the early 1960s, Lipton was one of the stars of the daytime television soap opera The Guiding Light, and in 1994 become the often-satirized host of the popular, long-running Bravo cable television interview program Inside the Actors Studio.