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The Big Trees was filmed on location in Williams Grove near Eureka, CA, the town of Orrick, CA and at properties belonging to the Carlotta Lumber Co. and the Hammond Lumber Co. According to studio press information in the production file on the film in the AMPAS Library, students from Humboldt State College played some of the parts of religious colonists and sang in the choir. The Daily Variety review noted that the picture incorporated footage, and certain plot elements, from the 1938 Warner Bros. film Valley of the Giants (see AFI Catalog of Feature Films, 1931-40). Although their appearance in the film has not been confirmed, July 1953 Hollywood Reporter news items add Cliff Lyons, Don Turner, Lane Chandler, William Vincent and Frank Hagney to the cast. A radio version of the film aired on Lux Radio Theatre on November 2, 1954, starring Van Heflin and Nancy Gates in the Kirk Douglas and Eve Miller roles.