Greg Focker is head over heels in love with his girlfriend Pam, and is ready to pop the big question. Greg realizes the key to Pam's hand in marriage lies with her formidable father, Jack Byrnes. A trip to New York for her sister's wedding seems just the right occasion for Greg to ask Pam to be his wife. But everything that could possibly go wrong, does. Upon his arrival at the family's picturesque home, Greg is greeted by what appears to be the picture-perfect family. But for a guy who usually resorts to dry wit in stressful situations, Greg is suddenly shooting blanks with Jack, a retired horticulturist--and rather imposing figure. No one is good enough for Jack's first-born daughter, and the fact that Greg is a cat-hating male nurse with a vulgar-sounding last name is not helping things at all. While Greg bends over backwards to try and make a good impression, his weekend begins with lost luggage at the airport and turns into a series of disasters.

Greg Focker's all set to propose to his girlfriend Pam during a weekend at her parents' home. But Pam's intimidating, ex-CIA father, Jack Byrnes, takes an immediate dislike to Greg after a string of mishaps turns him into a master of disaster.