- Clint Eastwood's role was first offered to Henry Fonda and Charles Bronson.
- Eastwood helped in creating his character's distinctive visual style. He bought the black jeans from a sport shop on Hollywood Boulevard, the hat came from a Santa Monica wardrobe firm, and the trademark black cigars came from a Beverly Hills' store.
- Because this was an Italian/German/Spanish co-production, there was a significant language barrier on the set. Eastwood communicated with Leone and the Italian crew mostly through stuntman Benito Stefanelli, who also acted as an unofficial interpreter for the production.
- A remake of Yojimbo (1961)
- When the film was shown on American Television station ABC in the early 70's, additional footage was shot to give the "Man with no Name" character a motive for going to the town (San Miguel) featured in the film. Neither Eastwood nor Leone were involved in the shooting of this additional footage. Harry Dean Stanton (uncredited) played an unidentified lawman or politician who orders Eastwood to get rid of the gangs of San Miguel in return for a pardon. Stock footage of Eastwood was used. This footage apparently no longer exists, although a copy of Dean's script did survive.
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