Nick Marshall, a Chicago advertising executive, gets a whole new outlook on life when a fluke accident gives him the ability to read women's minds. At first, this "gift" provides Nick with way too much information, but he begins to realize that he can use it to good effect, especially when it comes to outwitting his new boss, Darcy Maguire. In spite of his best efforts to finesse Darcy, he soon finds himself falling in love and truly understanding what women want.

A male advertising executive gains the ability to read women's minds - for better or worse.