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Variety notes that George Brent was to have played Dr. Burton but asked to be released as he did not want to make the trip to the ten-day Stockton location on the San Joaquin River. His wife, Ruth Chatterton, had previously turned down the lead because she did not want to play another prostitute. News items in Hollywood Reporter note that Donald Woods later was assigned to the lead and Katya Sergova was considered for "Tanya." According to Hollywood Reporter, the script had to be rewritten to explain Lyle Talbot's head bandage, the result of an earlier accident. In 1936, the studio's application for a certificate of approval for re-issue was denied. A letter from Joseph Breen, Director of the Studio Relations office of the AMPPA to Jack L. Warner dated September 3, 1936 lists the films for which certificates had been denied because "The examination of our files would indicate that they contain so much objectionable matter that any attempt to re-edit them so as to bring them within the requirements of the Production Code would be extremely difficult. About Mandalay the letter added, "This picture also has the basic Code violation of presenting the heroine as an immoral woman."