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The working titles of this film were Rope's End and Fort Bravo. The order of cast names in the opening credits is different from that of the end credits, in which the leading actors are billed last. Hollywood Reporter news items report that Keenan Wynn was originally cast as "Cabot Young," but William Campbell took over the role when Wynn was injured in an automobile accident. According to an March 11, 1953 Hollywood Reporter news item, James Whitmore was cast in a top role, but he was not in the film. A Hollywood Reporter news item adds Howard Wilson to the cast, but his appearance in the completed film has not been confirmed. Most of the film was shot on location in Gallup, NM and at Death Valley National Monument, CA.
According to information in the file on the film in the MPAA/PCA Collection at the AMPAS Library, composer Jeff Alexander submitted two additional songs, "Battle of Chanc'llorville" and "Rebel's Rant," that were not used in the final film. According to contemporary news items and reviews, Escape from Fort Bravo was the first film made using M-G-M's own wide-screen process, which Variety noted had an aspect ratio of 1.66:1.