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The opening credits for the film begin "Solar Film Productions Limited presents Edgar Rice Burrough's Tarzan and the Lost Safari in Eastman Color." This film was the first in the "Tarzan" series to be shot in color. A June 3, 1956 Daily Variety article states that Victor Stoloff was to direct the film, but he was later replaced by Bruce Humberstone. Although most of the Tarzan pictures featured the character "Jane," Tarzan's mate, she was not mentioned in Tarzan and the Lost Safari. In addition to shooting at the Associated British Pictures Corp. Studios in London, portions of the film were shot on location near Nairobi, British East Africa. As noted in modern sources, Gordon Scott was on location in Africa and did some of the stunt work playing with the rhinoceros and a baby elephant as portrayed onscreen.
According to a October 1, 1956 Hollywood Reporter article, Tarzan and the Lost Safari was originally to be distributed by RKO, which had distributed earlier Sol Lesser "Tarzan" films; however, a January 24, 1957 Hollywood Reporter article states that Universal-International acquired the sale and distribution rights for all RKO products, which caused concern among independent producers, who had not been consulted prior to the deal. A February 13, 1957 Daily Variety article states that producer Lesser subsequently made a deal with M-G-M's distribution arm, Loew's Inc., which had distributed a rival Tarzan series in the 1930s and early 1940s, to distribute Tarzan and the Lost Safari. For more information about the series, see the entries for Tarzan, the Ape Man in AFI Catalog of Feature Films, 1931-40 and Tarzan Triumphs in AFI Catalog of Feature Films, 1941-50, and consult the Series Index.