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Although an October 1951 Hollywood Reporter news item states that Frankie Hyers was set to portray the private detective, that role was played by Ian MacDonald in the final film. According to an August 1951 Hollywood Reporter news item, Ted Sherdeman was assigned to write the script, but his contribution to the film, if any, has not been determined. A November 1951 Hollywood Reporter news item announced that Max Steiner was assigned to do the score, but David Buttolph composed the score for the released film. Although Oliver S. Garretson is credited onscreen as sound man, early production charts list Les Hewitt. Hollywood Reporter news items add the following members to the cast: James Moore, Alma Mansfield, Robert "Buddy" Shaw, Lester Sharpe, Ray Rachlkowski, Les O'Pace and Jason Lindsey. Their appearance in the final film has not been confirmed. Portions of the film were shot in Pasadena and at the Los Angeles County Hospital, according to October 1951 Hollywood Reporter news items.
This Woman Is Dangerous was Joan Crawford's last Warner Bros. film until Whatever Happened to Baby Jane in 1962. According to a modern source, Warner offered Crawford the part of "Beth Austin" hoping the difficult actress would refuse to play the role and thereby provide grounds for the studio to break contract. Dennis Morgan reprised his role on March 16, 1953 in a Lux Radio Theatre production, co-starring Virginia Mayo and Leif Erickson.