Following the film's closing credits, there appears a written acknowledgment to the Navy and Defense Departments and dedication to the Destroyer Forces of the United States Navy. The Deep Six was produced by actor and producer Alan Ladd's company, Jaguar Productions, Inc. According to a July 7, 1957 Los Angeles Examiner article, Cmdr. Eldon Edwards, USN, commanded the U.S.S. Stephen Potter, a Fletcher Class destroyer chosen to represent the "U.S.S. Poe" because of its use in World War II. Improvements to the ship made after the war were removed to make the ship resemble the original, and period gun mounts were added.
       Hollywood Reporter news items add the following actors to the cast; however their appearance in the final film has not been confirmed: Robert Levin, Jack Mann and Alana Ladd, daughter of Alan and Sue Carol Ladd. According to a July 7, 1957 New York Times article, George A. Smith and Albert D. Peters, members of the U.S.S. Potter crew, also had roles in the film. Location shooting took place at the Long Beach Harbor, Carmel and San Francisco, CA. The Deep Six marked the feature film debut of comedian Joey Bishop.