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The working title of this film was The Thin Man's Rival. Various contemporary news items indicate that the film was originally set to begin production in June 1942 but was shelved when Myrna Loy, William Powell's co-star in previous "Thin Man" films, refused the assignment. Loy left California for New York in December 1941 to marry car rental heir John Hertz, Jr., and soon after began a lengthy leave of absence from films to work for the Red Cross war relief effort. In November 1942, a Hollywood Reporter news item announced that the film was to begin production with Irene Dunne as "Nora Charles." The film was shelved again a short time later and did not receive mention in Hollywood Reporter until March 1944, when a news item noted that Loy was set to do the film. The Thin Man Goes Home was Loy's only wartime film.
According to an April 1944 Hollywood Reporter news item, wartime liquor rationing prompted producer Everett Riskin to eliminate the heavy drinking that had been an integral part of "Nick" and "Nora's" daily life in previous "The Thin Man" films. According to Hollywood Reporter, Norman Taurog directed the added scenes in August and September 1944, while Richard Thorpe began work on his next film, Thrill of a Romance (see below). Cameraman Joseph Ruttenberg filled in for Karl Freund in June 1944 while Freund was recovering from an illness.
A New York Times article notes that the dog that played "Asta" in previous "Thin Man" films "outgrew" its part and was replaced by another dog for this film. The same article also noted that the film was budgeted at $1,000,000, which was considerably less than the $2,500,000 budgeted for the most expensive film in the series. Hollywood Reporter production charts list actor Douglas Morrow in the cast and Hollywood Reporter news items list Mickey Roth in the cast, but their appearance in the released film has not been confirmed. The film marked the last screen appearance of actress Helen Vinson. The film was the fifth in the "Thin Man" series. W. S. Van Dyke, who directed the first four films in the series, died in 1943. For more information on the series, please consult the Series Index and see the entry for The Thin Man in AFI Catalog of Feature Films, 1931-40; F3.4572.