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Working titles for the film were Creature from Blood Island, The Gory Creatures, Island of Terror and Blood Creature. Although there is a copyright statement on the film, it was not registered for copyright. However, a videocassette of the film was copyrighted in 1998 to Hemishpere Entertainment under the number PA903-168. The following written prologue appears before the film's credits: "Warning-The picture you are about to see has a scene so shocking that it is necessary to forewarn you. We suggest that the squeamish and faint-hearted close their eyes at the sound of the bell and reopen them when the bell rings again. The Management."
The sound of a bell is heard just prior to a close-up shot showing "Dr. Girard" cutting an incision into the "Panther man." The New York Times review noted that if the film's topic was not sufficiently frightening to viewers, the startling sound of the bell would suffice. The film was shot in its entirety in Manila, Philippines, according to the onscreen credits. Although Terror Is a Man has some similarities to H. G. Wells's novel, The Island of Dr. Moreau, it was not acknowledged as a source for the film.